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In vitro reports, 25C-NBOMe has become shown to show cytotoxicity on neuronal cell strains SH-SY5Y, PC12, and SN471, as well as the compound was more powerful than methamphetamine at lowering the visibility of your respective cells; the neurotoxicity on the compound entails activation of MAPK/ERK cascade and inhibition of Akt/PKB signaling pathway.